A reservation is required to drive into or through Yosemite National Park on some days from April 13 through October 27, 2024, for those driving into the park between 5 am and 4 pm as follows:. April 13 through June 30: A reservation is required from 5 am to 4 pm on Saturdays, Sundays, and on holidays (May 27 and June 19).A reservation is not required on other days.. Highway 41 to Yosemite Valley. The quickest, most popular route once you're out of Los Angeles is to take I-5 north to Highway-99 north to Highway-41 north and continue into Yosemite Valley. Down in the valley, there are numerous hiking trails, a visitor center, food options, and accommodations.

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There are two primary routes to take from Los Angeles to Yosemite National Park. One is on CA-99 and is a much more direct shot. Using this route on your trip to Yosemite will cover about 280 miles. The longer and more scenic route will bring you along the Pacific Coast Highway and is about 335 miles or longer if you make a stop in San Francisco.. The distance from Los Angeles to Yosemite via the traditional CA-99 route is 279 miles and takes about 5 hours. In contrast, the US-395 N route is 334 miles. The extra miles bring the Los Angeles to Yosemite drive time up to nearly 6 hours. This drive can easily be done in a day with just a few stops at some of the most interesting locations.